Super Feather Weight
Vázquez embarked on his professional boxing career on January 20, 2006, facing a young Canelo Álvarez when Álvarez was just fifteen years old, in a welterweight bout. Vázquez, unfortunately, lost that match in a four-round split decision. Nevertheless, he went on to win his next eighteen fights before encountering another loss, this time to Timothy Bradley on July 27, 2007, in a contest for the WBC Youth super lightweight title. Bradley praised Vázquez’s skills and toughness, acknowledging the challenging nature of the fight.
In June 2008, Vázquez secured the WBC FECARBOX light welterweight title by defeating the seasoned Aldo Valtierra via technical knockout after eleven rounds. However, this fight faced criticism from a ringside doctor due to its one-sided nature and potential risks to Valtierra’s well-being.
A rematch against Canelo Álvarez took place on June 28, 2008, this time in the light middleweight category, where Vázquez suffered a ten-round unanimous decision loss.
One of Vázquez’s notable victories came on July 17, 2009, when he secured a ten-round split decision win over the previously undefeated and highly ranked Breidis Prescott. Although Prescott scored an early knockdown, Vázquez’s superior boxing skills enabled him to accumulate rounds and ultimately secure the victory.
Vázquez’s reign as a lightweight champion began on August 14, 2010, when he faced Ji-Hoon Kim for the vacant IBF lightweight title. He won the world title with a unanimous decision victory. He successfully defended his title for the first time against Ricardo Dominguez on November 27, 2010, with another wide unanimous decision.
Subsequent title defenses followed, including a notable victory against the undefeated Leonardo Zappavigna on March 12, 2011, where Vázquez showcased his boxing prowess by outboxing his opponent over the twelve-round distance. He continued his successful title defenses, defeating Ammeth Díaz and Marvin Quintero, the latter on the HBO platform.
A significant bout was scheduled for Vázquez against Ricky Burns in a unification match on March 16, 2013, but it was later postponed due to Vázquez’s viral infection resulting from food poisoning. The fight ultimately fell apart.
In February 2014, Vázquez secured a decision victory against Denis Shafikov in Macau.
Throughout his title reign, Vázquez faced criticism for his fighting style, which some considered boring. He often focused on controlling the distance, using footwork and jabs while also employing tactics like headbutts and excessive clinching to outmaneuver opponents.
On September 13, 2014, Vázquez faced Mickey Bey on the undercard of Floyd Mayweather Jr. vs. Marcos Maidana II. Vázquez lost the IBF title in a split decision, marking his first defeat since 2008. The decision was contentious, with many ringside observers believing that Vázquez had won the fight, particularly questioning the scorecard of 119–109 by Robert Hoyle.